They have oestrogenic effects on living organisms…
Xenoestrogens are widely used industrially made compounds such as PCB, BPA and Phthalates. They are chemically different from human oestrogens, but they have oestrogenic effects on living organisms. Because these xenoestrogens come into the environment through pesticides, herbicides, plastic and because they are widely used in medication, cosmetics and cattle breeding, the world population suffers more and more under these xenoestrogens (Korach & Kenneth 1998).
Xenoestrogens have an influence on the reproduction. Endometriosis and loss of fertility in both men and women are known effects. They also play a role in the oncogenesis (Darbre 2006, Darbre et al 2004, Buterin et al 2006, Pugazhendhi et al 2007, Safe 2004).
Breast development in children and in men with metabolic syndrome are consequences of xenoestrogens environmental intake. Several chronic diseases such as arthritis, Myalgic encephalomyelitis – ME or Post-Viral Fatigue Syndrome - PFS tend to stand under the influence of this slow toxic intake.
Phytoestrogens or dietary oestrogens as they appear in different food such as soya have the same oestrogen effect when taken in too high quantities.
• Buterin T, Koch C, Naegeli H (August 2006). "Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells". Carcinogenesis 27 (8): 1567–78.
• Darbre PD (March 2006). "Environmental oestrogens, cosmetics and breast cancer". Best Pract. Res. Clin. Endocrinol. Metab. 20 (1): 121–43.
• Darbre PD, Aljarrah A, Miller WR, Coldham NG, Sauer MJ, Pope GS (2004). "Concentrations of parabens in human breast tumours". J Appl Toxicol 24 (1): 5–13.
• Korach, Kenneth S. (1998). Reproductive and Developmental Toxicology. Marcel Dekker Ltd. pp. 278–279, 294–295.
• Pugazhendhi D, Sadler AJ, Darbre PD (2007). "Comparison of the global gene expression profiles produced by methylparaben, n-butylparaben and 17beta-oestradiol in MCF7 human breast cancer cells". J Appl Toxicol 27 (1): 67–77.
• Safe S (December 2004). "Endocrine disruptors and human health: is there a problem". Toxicology 205 (1-2): 3–10.