Specialized cutaneous Schwann cells initiate pain sensation

A newly discovered cell type for pain perception

Pain has been thought to be initiated by activation of free nerve endings without end organs in the skin. In contrast to this paradigm, Abdo et al. discovered a previously unknown meshlike organ covering the skin that senses dangerous environmental stimuli. This organ is built from specialized glial cells located in the epidermal-dermal border and is sufficient and required for initiation of mechanical pain transduction.


Hind Abdo, Laura Calvo-Enrique , Jose Martinez Lopez, Jianren Song, Ming-Dong Zhang, Dmitry Usoski, Abdeljabbar El Manira, Igor Adameyko, Jens Hjerling-Leffler, Patrik Ernfors

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