The heart muscle is one of the least renewable tissues in the body, which is one of the reasons that heart disease is the leading cause of death for both men and women.

Inspired by the idea of helping the heart repair itself, researchers at Baylor College of Medicine and the Texas Heart Institute have studied pathways known to be involved in heart cell functions and discovered a previously unknown connection between processes that keep the heart from repairing itself.

Journal reference: Yuka Morikawa, Todd Heallen, John Leach, Yang Xiao, James F. Martin. Dystrophin glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation. Nature, 2017; DOI: 10.1038/nature22979